TY - JOUR AU - Cruz, Gloria AU - Nie, Shengdong AU - Wang, Lijia PY - 2014/12/01 Y2 - 2024/03/28 TI - Potential application of ivim and dwi imaging in parkinson’s disease JF - Tecnura JA - Tecnura VL - 18 IS - 0 SE - Investigación DO - 10.14483/22487638.9245 UR - https://revistas.udistrital.edu.co/index.php/Tecnura/article/view/9245 SP - 80-89 AB - <p>Parkinson’s disease (PD) is a progressive degenerative neurological condition, which origin remains unclear. We are interested in proposing the study of<br />blood flow in the substantia nigra (SN) in PD patients, based on findings that demonstrated relative hypoactivity in PD patients located to subthalamic<br />nucleus and SN. It is believed that this hipoactivity may suggest changes in the blood flow to the SN, where the particular loss of dopaminergic neurons<br />occurs.</p><p>The method used is the Incoherent Motion Intravoxel (IVIM) that allows measurement of blood flow to the microvascular level and recently has been producing high resolution quantitative perfusion maps.<br />This paper proposes to measure the perfusion in PD patients and find any correlation with neural activity and water displacements within the<br />tissue. Assuming decreasing the local perfusion suggests the possible impairments that affect the neural activity in PD causing the progressive<br />death of neurons in the SN.</p> ER -