Potential application of ivim and dwi imaging in parkinson’s disease

  • Gloria Cruz Universidad Antonio Nariño
  • Shengdong Nie University China
  • Lijia Wang University China
Palabras clave: Parkinson's disease (PD), Intravoxel incoherent motion (IVIM), Diffusion Weighted Imaging (DWI), Substantia nigra (SN). (en_US)
Palabras clave: Diffusion Weighted Imaging (DWI), Intravoxel incoherent motion (IVIM), , Parkinson’s disease (PD), Substantia nigra (SN). (es_ES)

Resumen (en_US)

Parkinson’s disease (PD) is a progressive degenerative neurological condition, which origin remains unclear. We are interested in proposing the study of
blood flow in the substantia nigra (SN) in PD patients, based on findings that demonstrated relative hypoactivity in PD patients located to subthalamic
nucleus and SN. It is believed that this hipoactivity may suggest changes in the blood flow to the SN, where the particular loss of dopaminergic neurons
occurs.

The method used is the Incoherent Motion Intravoxel (IVIM) that allows measurement of blood flow to the microvascular level and recently has been producing high resolution quantitative perfusion maps.
This paper proposes to measure the perfusion in PD patients and find any correlation with neural activity and water displacements within the
tissue. Assuming decreasing the local perfusion suggests the possible impairments that affect the neural activity in PD causing the progressive
death of neurons in the SN.

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Biografía del autor/a

Gloria Cruz, Universidad Antonio Nariño

MSc. Received her B.A degree in Biomedical Engineering at Universidad Antonio Nariño, Colombia, in 2000, the MSc. degree in Biomedical Engineer at The Beijing Institute of Technology, China, in 2010. She is currently a Senior Research Lecturer in Neuroscience and Neurocomputing
and pursuing his PhD. degree within The University of Shanghai for Science and Technology. Her current researches interesting include Diffusion Tensor Imaging, Diffusion Weight Imaging, Perfusion Imaging, cancer and neuronal degenerative diseases.

Shengdong Nie, University China

PhD. Received his Bachelor degree in Mathematics and Control Theory from Shandong University, China, in 1984. He was an assistant engineer in Ministry of Defense for Simulation System Laboratory and Department of Radiology at the Computer Medical College, during
1984-1990. He received his Master’s degree in Automation Engineering from Electrical Shandong University of Science and Technology. He received his PhD degree in Biomedical Engineering from Jiaotong University, China, in 2000. He is now associate Professor and leader inUniversity of Shanghai for Science and Technology at the Institute Medical Imaging Engineering.

Lijia Wang, University China

PhD. She was born in 1984. She accepted her physics PhD degree from East China Normal University, China, on July, 2014. Her project is mainly focused on MRI techniques mainly including fully automated segmentation of cine cardiac MRI images. She also worked on fMRI
study of visual illusory motion. Four paper and 7 patents have been published. Now she is working on MRI Pulse sequence design.

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Cómo citar
Cruz, G., Nie, S., & Wang, L. (2014). Potential application of ivim and dwi imaging in parkinson’s disease. Tecnura, 18, 80-89. https://doi.org/10.14483/22487638.9245
Publicado: 2014-12-01
Sección
Investigación