Etnofarmacología, bioactividad y fitoquímica de <i>Maxillaria densa</i> Lindl. Revisión científica y biocomercio en el neotrópico

Ethnopharmacology, bioactivity and phytochemistry of <i>Maxillaria densa</i> Lindl. Scientific review and Biotrading in the neotropics

Palabras clave: phenanthrene derivatives, antispasmodic, antinociceptive, bioeconomy (en_US)
Palabras clave: derivados del fenantreno, antiespasmódico, antinociceptivo, bioeconomía (es_ES)

Resumen (es_ES)

Maxillaria densa es una orquídea oriunda de América Central extendida en alta montaña y bosques húmedos. El objetivo de esta revisión es proporcionar un análisis crítico sobre etnofarmacología, fitoquímica y farmacología de la especie, enfocándose en su potencial para el biocomercio. Para encontrar sus compuestos bioactivos fueron exploradas las bases de datos de PubMed, Scopus, SciELO y SciFinder, Sciencedirect, Springer, la editorial Elsevier y webs especializadas, de esta manera se confirmó cuáles son los compuestos y propiedades de esta planta. M. densa es usada tradicionalmente para el tratamiento de dolores estomacales, como antidiarreico y antiespasmódico. Los extractos obtenidos de M. densa muestran la presencia de seis principios activos derivados del fenantreno, un hidrocarburo policíclico aromático. Los estudios de actividad biológica realizados han evidenciado efectos espasmolíticos, antinociceptivos y relajantes. M. densa crece en cultivos de café bajo sombra, que son considerados sistemas de producción sostenibles, aumentando las posibilidades de negocios verdes por agricultores locales. A partir de los hallazgos mencionados, M. densa presenta un potencial como fuente de moléculas bioactivas y como flor ornamental, abriendo una nueva perspectiva en el ámbito de la bioeconomía.

Resumen (en_US)

Maxillaria densa is a native American orchid extended in high mountains and humid forests. The objective of this review is to provide a critical analysis on ethnopharmacology, phytochemistry and pharmacology of the species, focusing on its potential for biotrading.

The study was conducted exploring the PubMed, Scopus, SciELO and SciFinder databases and specialized websites, looking for bioactive molecules and thus confirming what properties and compounds contain this plant. M. densa is traditionally used for the treatment of stomach pains, such as antidiarrheal and antispasmodic. The extracts obtained from M. densa show the presence of six active ingredients derived from phenanthrene, an aromatic polycyclic hydrocarbon. The biological activity studies carried out have shown spasmolytic, antinociceptive and relaxing effects. M. densa grows in coffee crops under shade, which are considered sustainable production systems, increasing the chances of green businesses for local farmers. From the mentioned findings, M. densa presents a potential as a source of bioactive molecules and as an ornamental flower, opening a new perspective in the Bioeconomy field.

Descargas

La descarga de datos todavía no está disponible.

Referencias

Araújo-Lima, C. F., da Silva-Oliveira, J. P., Leite-Coscarella, I., Fortes-Aiub, C. A., Felzenszwalb, I., Caprini-Evaristo, G. P. y Furtado-Macedo, A. (2020). Metabolomic analysis of Cyrtopodium glutiniferum extract by UHPLC-MS/MS and in vitro antiproliferative and genotoxicity assessment. Journal of Ethnopharmacology, 253.

https://doi.org/10.1016/j.jep.2020.112607.

Arora, M., Mahajan, A. y Sembi J. K. (2017a). A review on phytochemical and pharmacological potential of family Orchideaceae. International Research Journal of Pharmacy, 8(10), 9-24.

https://doi.org/10.7897/2230-8407.0810176

Arora, M., Singh, S., Mahajan, A. y Sembi J. K. (2017b). Propagation and Phytochemical Analysis of Crepidium acuminatum (D.Don) Szlach. Journal of Pharmacy and Biological Sciences, 12(3), 14-20.

https://doi.org/10.9790/3008-1203071420

Bhalla, Y., Gupta, V. K y Jaitak V. (2013). Anticancer activity of essential oils: a review. Journal of the Science of Food and Agriculture, 93, 3643-3653.

https://doi.org/10.1002/jsfa.6267

Blanco, M. A. (2013). New combinations and synonysm in the Maxillariinae (Orchidaceae). Selbyana, 31(1), 52-59.

https://www.jstor.org/stable/24894276.

Blanco, M. A., Carnevali, G., Whitten, W. M., Singer, R. B., Koehler, S., Williams, N. H., Ojeda, I., Neubig, K. M. y Endara, L. (2007). Generic realignments in Maxillariinae (Orchidaceae). Lankesteriana International Journal on Orchidology, 7(3), 515-537.

https://doi.org/10.15517/lank.v0i0.7935

Bodnar, J. R. (2008). Endogenous opiates and behavior: 2007. Peptides, 29(12), 2292-2375.

https://doi.org/10.1016/j.peptides.2008.09.007

Cakova, V., Bonte F. y Lobstein A. (2017). Dendrobium: sources of active ingredientes to treat age-related pathologies. Aging and Disease, 8(6), 827-849.

https://doi.org/10.14336/AD.2017.0214

Chen, K. K. y Chen, A. L. (1935). The alkaloid of Chin-Shih-Hu. Journal of Biological Chemistry, 111, 653-658.

Chen, C. C., Huang, Y. L. y Teng, C. M. (2000). Antiplatelet Aggregation Principles from Ephemerantha lonchophylla. Planta Medica, 66, 372-374.

Comisión Nacional para el Conocimiento y Uso de la Biodiversidad (2013). La biodiversidad en Chiapas: estudio de estado. México: Gobierno del Estado de Chiapas; Comisión Nacional para el Conocimiento y Uso de la Biodiversidad.

De, L. C., Pathak., P., Rao, A. N. y Rajeevan, P. K. (2015). Commercial Orchids. Berlin: De Gruyter Open, Publisher.

Déciga-Campos, M., Palacios-Espinosa, J.F., Reyes Ramírez, A. y Mata, R. (2007). Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. Journal of Ethnopharmacology, 114(2), 161-168.

https://doi.org/10.1016/j.jep.2007.07.021

Dodson, C. (2002) Maxillaria. Native Ecuadorian Orchids. Vol. III: Lepanthopsis-Oliveriana. Quito: Imprenta Mariscal.

Espejo-Serna, A., López-Ferrari, A. R., Jiménez-Machorro, R. y Sánchez-Saldaña L. (2005). Las orquídeas de los cafetales en México: una opción para el uso sostenible de ecosistemas tropicales. Revista de Biología Tropical, 53(1-2), 73-84.

Estrada, S., Toscano, R. A. y Mata, R. (1999). New Phenanthrene Derivatives from Maxillaria densa. Journal of Natural Products. 62(8), 1175-1178.

https://doi.org/10.1021/np990061e

Estrada, S., López-Guerrero, J. J., Villalobos-Molina, R. y Mata, R. (2004). Spasmolytic stilbenoids from Maxillaria densa. Fitoterapia. 75(2004), 690-695.

https://doi.org/10.1016/j.fitote.2004.08.004

Hinsley, A., Verissimo, D. y Roberts, D. L. (2015). Heterogeneity in consumer preferences for orchids in international trade and the potential for the use of market research methods to study demand for wildlife. Biological Conservation, 190, 80-86.

https://doi.org/10.1016/j.biocon.2015.05.010.

Hernández-Alcázar, J. A., Sarmiento, O. F. y Beutelspacher, C. R. (2017). Orquídeas en huertos familiares de Pantelhó, Chiapas, México. Lacandonia,11(1), 11-18.

Hernández-Romero, Y., Rojas, J.I., Castillo, R., Rojas, A. y Mata R. (2004). Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii. Journal of Natural. Products, 67(2), 160-167.

https://doi.org/10.1021/np030303h

Hwang, J. S., Lee, S. A., Hong, S. S., Han, X. H., Lee, C., Kang, S. J., Lee, D., Kim, J., Hong, J. T., Lee, M. K. y Hwang, B. Y. (2010). Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells. Bioorganic & Medicinal Chemistry Letters, 20(12), 3785-3787.

https://doi.org/10.1016/j.bmcl.2010.04.054

Hossain, M. M. (2011). Therapeutic orchids: traditional uses and recent advances — An overview. Fitoterapia, 82(2), 102-140.

https://doi.org/10.1016/j.fitote.2010.09.007.

Jiménez, T., Cárdenas, J. y Soler-Tovar, D. (2017). Editorial: Biocomercio en el contexto suramericano: Colombia y Perú como estudios de caso. Revista Medicina Veterinaria, 35, 9-15.

https://doi.org/10.19052/mv.4385

Khan, H., Belwal, T., Tariq, M., Atanasov, A. G. y Devkota, H. P. (2019). Genus Vanda: A review on traditional uses, bioactive chemical constituents and pharmacological activities. Journal of Ethnopharmacology, 229, 46-53.

https://doi.org/10.1016/j.jep.2018.09.031.

Khazir, J., Riley, D. L., Pilcher, L. A., Pieter De-Maayer, P. y Mir, B. A. (2014). Anticancer Agents from Diverse Natural Sources. Natural Product Communications, 9(11).

https://doi.org/10.1177/1934578x1400901130

Kovács, A., Vasas, A. y Hohmann, J. (2008). Natural phenanthrenes and their biological activity. Phytochemistry, 69, 1084-1110.

https://doi.org/10.1016/j.phytochem.2007.12.005

Mata, R., Figueroa, M., Gonzaĺez-Andrade, M., Rivera-Chav́ez, J. A., Madariaga-Mazoń, A. y Del Valle P. (2014). Calmodulin inhibitors from natural sources: An Update. Journal of Natural Products, 78(3), 576-586.

https://doi.org/10.1021/np500954x

Milián, L., Estellés, R., Abarca, B., Ballesteros, R., Sanz, M. J. y Blázquez M. A. (2004). Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from Natural Boldine. Chemical and Pharmaceutical Bulletin, 52(6), 696-699.

Myers, N., Mittermeier, R. A., Mittermeier, C. G., da Fonseca, G. A. B. y Kent, J. (2000). Biodiversity hotspots for conservation priorities. Nature, 403(6772), 853-858.

https://doi.org/10.1038/35002501

Muradian, R., Verschoor, G., Bolívar, E. y Ochoa G. I. (2012). Construyendo Cadenas de valor incluyentes: una comparación de dos casos de biocomercio en suramérica. Mundo Amazónico, 3, 43-69.

https://doi.org/10.5113/ma.3.16736.

Murillo, C. R. y Arias R. R. (2008). Biocomercio: una alternativa para el desarrollo sostenible. Ciencias Económicas, 26(1), 73-90.

Newman, D. J. y Cragg, G. M. (2007). Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70(3), 461-477.

https://doi.org/10.1021/np068054v

Ng, T. B., Liu, J., Wong, J. H., Ye, X., Wing Sze, S. C., Tong, Y. y Zhang, K. Y. (2012). Review of research on Dendrobium, a prized folk medicine. Applied Microbiology and Biotechnology, 93(5), 1795-1803.

https://doi.org/10.1007/s00253-011-3829-7.

Pérez-Gutierrez, R. M. (2010). Orchids: A review of uses in traditional medicine, its phytochemistry and pharmacology. Journal of Medicinal Plants Research, 4(8), 592-638.

https://doi.org/10.5897/JMPR10.012

Pizano, M. (2005). International market trends-tropical flowers. Acta Horticulturae, 683, 79-86. https://doi.org/10.17660/ActaHortic.2005.683.6

Pezzani, R., Salehi, B., Vitalini, S., Iriti, M., Zuñiga, F. A., Sharifi-Rad, J., Martorell, M. y Martins N. (2019). Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective. Medicina, 55(4), 110.

https://doi.org/10.3390/medicina55040110

Ramírez-Galicia, G., Garduño-Juarez, R., Hemmateenejad, B., Deeb, O. y Estrada-Soto, S. (2007). QSAR Study on the relaxant agents from some mexican medicinal plants and synthetic related organic compounds. Chemical Biology and Drug Design, 70(2), 143-153.

https://doi.org/10.1111/j.1747-0285.2007.00527.x

Rejhová, A., Opattová, A., Cumová, A., Slíva, D. y Vodička P. (2018). Natural compounds and combination therapy in colorectal cancer treatment. European. Journal of Medicinal Chemistry, 144, 582-594.

https://doi.org/10.1016/j.ejmech.2017.12.039

Ren, J., Qian, X. P., Guo, Y. G., Li, T., Yan, S. K., Jin, H. Z. y Zhang, W. D. (2016).Two new phenanthrene glycosides from Liparis regnieri Finet and their antibacterial activities. Phytochemistry Letters, 18, 64-67.

https://doi.org/10.1016/j.phytol.2016.08.023

Rendoń-Vallejo, P., Hernández-Abreu, O., Vergara-Galicia, J., Millán-Pacheco, C., Mejia, A., Ibarra-Barajas, M. y Estrada-Soto, S. (2012). Ex Vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa. Journal of Natural Products, 75(12), 2241-2245.

https://doi.org/10.1021/np300508v

Sablón-Cossío, N., Radice, M., Luna-Murillo, M. y Manjarrez-Fuentes, N. (2016). Biocomercio y Biodiversidad en el Ecuador. Oportunidades. Revista Científica Ecociencia, 3(6), 1-27.

Salehi, B., Zucca, P., Sharifi‐Rad, M., Pezzani, R., Rajabi, S., Setzer, W. N., Varoni, E. M., Iriti, M., Kobarfard y F., Sharifi‐Rad, J. (2018). Phytotherapeutics in cancer invasion and metastasis. Phytotherapy Research, 32(8), 1-25.

https://doi.org/10.1002/ptr.6087

Schuiteman, A. y Chase. M. (2015). A reappraisal of Maxillaria (Orchidaceae). Phytotaxa, 225(1), 1-78.

https://doi.org/10.11646/phytotaxa.225.1.1

Schütte, G. (2018). What kind of innovation policy does the bioeconomy need? New Biotechnology, 40, 82-86.

https://doi.org/10.1016/j.nbt.2017.04.003

Solis-Montero, L., Flores-Palacios, A. y Cruz-Angón, A. (2005). Shade-Coffee plantations as refuges for tropical wild orchids in central Veracruz, México. Conservation Biology, 19(3), 908-916.

https://doi.org/10.1111/j.1523-1739.2005.00482.x

Sut, S., Maggi, F. y Dall’Acqua, S. (2017). Bioactive Secondary Metabolites from Orchids (Orchidaceae). Chemistry & Biodiversity, 14(11).

https://doi.org/10.1002/cbdv.201700172

The Plant List (2018). The Plant List. Version 1.1

http://www.theplantlist.org/

Toledo-Aceves, T., García-Franco, J. G., Hernández-Rojas, A. y Mac Millan K. (2012). Recolonization of vascular epiphytes in a shaded coffee agroecosystem. Applied Vegetation Science, 15, 99-107.

https://doi.org/10.1111/j.1654-109X.2011.01140.x

UNCTAD (2007). United Nations Conference on Trade and Development UNCTAD. BioTrade Initiative BioTrade Principles and Criteria. Nueva York y Genova: ONU.

Valencia-Islas, N.A., Paul, R. N., Shier, W. T., Mata, R. y Abbas, H. K. (2002). Phytotoxicity and ultrastructural effects of gymnopusin from the orchid Maxillaria densa on duckweed (Lemna pausicostata) frond and root tissues. Phytochemistry, 61(2), 141-148.

https://doi.org/10.1016/s0031-9422(02)00220-0

Whitten, W. M., Blanco, M. A., Williams, N. H., Koehler, S., Carnevali, G., Singer, R. B., Endara, L. y Neubig, K. M. (2007). Molecular phylogenetics of Maxillaria and related genera (Orchidaceae: Cymbidieae) based on combined molecular data sets. American. Journal of Botany, 94(11), 1860-1889.

https://doi.org/10.3732/ajb.94.11.1860

Wu, Y. P., Liu, W. J., Zhong, W. J., Chen, Y. J., Chen, D. N., He, F. y Jiang, L. (2017). Phenolic compounds from the stems of Flickingeria fimbriata. Natural Product research, 31(13), 1518-1522.

https://doi.org/10.1080/14786419.2017.1278599

Yánez P. M. y Granda M. J. (2016). Socio-environmental and conservation factors in Amazonian lands of Ecuador linked or not to the Socio Bosque program. Innova Research Journal, 1(11), 17-29.

https://doi.org/10.33890/innova.v1.n11.2016.56

Yoshikawa, K., Ito, T., Iseki, K., Baba, C., Imagawa, H., Yagi, Y., Morita, H., Asakawa, Y., Kawano, S. y Hashimoto T. (2012). Phenanthrene derivatives from Cymbidium great flower Marie Laurencin and their biological activities. Journal of Natural Products, 75(4), 605-609.

https://doi.org/10.1021/np200788u.

Yu, S., Wang, Z., Su, Z., Song, J., Zhou, L., Sun, Q., Liu, S., Li, S., Li, Y., Wang, M., Zhang, G.Q., Zhang, X., Liu, Z. J. y Lu, D. (2018). Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. Complementary and Alternative Medicine, 18(1), 18-59.

https://doi.org/10.1186/s12906-018-2108-x

Zhang, Y., Zhang, Q., Xin, W., Liu, N. y Zhang, H. (2019). Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells. Drug Design, Development and Therapy, 13, 2591-2601.

https://doi.org/10.2147/DDDT.S180610

Zambrano-Romero, B. J. y Solano-Gómez, R. (2016). Una nueva especie de Maxillaria (Orchidaceae: Maxillariinae) del suroccidente de Ecuador. Revista Mexicana de Biodiversidad, 87, 29-34.

https://doi.org/10.1016/j.rmb.2016.01.012

Cómo citar
Radice, M., Scalvenzi, L., & Gutierrez del Pozo, D. (2020). Etnofarmacología, bioactividad y fitoquímica de <i>Maxillaria densa</i&gt; Lindl. Revisión científica y biocomercio en el neotrópico. Colombia Forestal, 23(2), 20-33. https://doi.org/10.14483/2256201X.15924
Publicado: 2020-07-01
Sección
Artículos de investigación científica y tecnológica