Vol. 45 Núm. 3 (2022): septiembre-diciembre


Educación científica y tecnológica

Recientes investigaciones en la síntesis sustentable de pirazolinas

Recent Research on the Sustainable Synthesis of Pyrazolines


Palabras clave:

Pyrazolines, Synthesis, Chalcones, Cyclocondensation, Hydrazines (en).

Palabras clave:

Pirazolinas, Síntesis, Chalconas, Ciclocondensación, Hidrazinas (es).


Resumen (es)

En química medicinal, se dirigen continuamente extensos esfuerzos en investigación al descubrimiento de nuevos heterociclos con efectos farmacológicos apropiados. Específicamente, el papel de los derivados del pirazol en la química médica es vital debido a su amplia gama de actividades biológicas. Por esta notable observación, se desarrolla esta revisión con enfoque sobre los avances de procedimientos sintéticos eco-amigables en términos de rendimiento, tiempo de reacción corto y condiciones limpias en la obtención de 2-pirazolinas, a partir de un análisis bibliográfico de investigación que toma como referencia los años 2019 a 2021 con respecto a la obtención de estos sistemas en condiciones simplificadas y energéticamente sustentables.

Resumen (en)

In medicinal chemistry, extensive research efforts are continuously directed towards the discovery of new heterocycles with appropriate pharmacological effects. Specifically, the role of pyrazole derivatives in medical chemistry is vital, given its wide range of biological activities. In light of this notable observation, this review is carried out with a focus on advances in eco-friendly synthetic procedures in terms of performance, short reaction time, and clean conditions when obtaining 2-pyrazolines, based on a bibliographic analysis of research that takes the years 2019 to 2021 as a reference with regard to obtaining these systems in simplified and energy-sustainable conditions.

Biografía del autor/a

José-José De-La-Ossa-Alían, Universidad del Atlántico




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Cómo citar


Trilleras, J., De-La-Ossa-Alían, J.-J., & Pérez-Gamboa, A. (2022). Recientes investigaciones en la síntesis sustentable de pirazolinas. Revista Científica, 45(3), 315–327.


Trilleras, J., De-La-Ossa-Alían, J.-J. y Pérez-Gamboa, A. 2022. Recientes investigaciones en la síntesis sustentable de pirazolinas. Revista Científica. 45, 3 (sep. 2022), 315–327. DOI:


Trilleras, J.; De-La-Ossa-Alían, J.-J.; Pérez-Gamboa, A. Recientes investigaciones en la síntesis sustentable de pirazolinas. Rev. Cient. 2022, 45, 315-327.


TRILLERAS, J.; DE-LA-OSSA-ALÍAN, J.-J.; PÉREZ-GAMBOA, A. Recientes investigaciones en la síntesis sustentable de pirazolinas. Revista Científica, [S. l.], v. 45, n. 3, p. 315–327, 2022. DOI: 10.14483/23448350.19282. Disponível em: Acesso em: 26 sep. 2022.


Trilleras, Jorge, José-José De-La-Ossa-Alían, y Alfredo Pérez-Gamboa. 2022. «Recientes investigaciones en la síntesis sustentable de pirazolinas». Revista Científica 45 (3):315-27.


Trilleras, J., De-La-Ossa-Alían, J.-J. y Pérez-Gamboa, A. (2022) «Recientes investigaciones en la síntesis sustentable de pirazolinas», Revista Científica, 45(3), pp. 315–327. doi: 10.14483/23448350.19282.


J. Trilleras, J.-J. De-La-Ossa-Alían, y A. Pérez-Gamboa, «Recientes investigaciones en la síntesis sustentable de pirazolinas», Rev. Cient., vol. 45, n.º 3, pp. 315–327, sep. 2022.


Trilleras, J., J.-J. De-La-Ossa-Alían, y A. Pérez-Gamboa. «Recientes investigaciones en la síntesis sustentable de pirazolinas». Revista Científica, vol. 45, n.º 3, septiembre de 2022, pp. 315-27, doi:10.14483/23448350.19282.


Trilleras, Jorge, José-José De-La-Ossa-Alían, y Alfredo Pérez-Gamboa. «Recientes investigaciones en la síntesis sustentable de pirazolinas». Revista Científica 45, no. 3 (septiembre 7, 2022): 315–327. Accedido septiembre 26, 2022.


Trilleras J, De-La-Ossa-Alían J-J, Pérez-Gamboa A. Recientes investigaciones en la síntesis sustentable de pirazolinas. Rev. Cient. [Internet]. 7 de septiembre de 2022 [citado 26 de septiembre de 2022];45(3):315-27. Disponible en:

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